Miami traveled to Louisville for the regional and opened up play against Oklahoma State. Things would start well for the Canes as they shutout the Cowboys by a score of 7-0. Chris Diaz was great once again as he went seven scoreless innings and allowed just three hits and struck out ten. Garrett Kennedy and Tyler Palmer had big days offensively as Kennedy was 3-4 with a home run, 3 RBIs, and 2 runs scored, while Palmer was 3-4 with a double and 2 runs scored. Chantz Mack also chipped in going 2-3 with an RBI and a run scored. After Diaz exited the game, Javi Salas tossed a scoreless 8th and Jace Herrera finished off the Cowboys throwing a scoreless 9th. Chris Diaz improved his record to 7-5 and finished the season with a 1.64 ERA.
Since Miami beat Oklahoma State, they took on host Louisville in the winners bracket game after they defeated Bowling Green. The Canes sent Bryan Radziewski to the mound and he dazzled with his curveball, but would ultimately run out of gas in the 7th inning. This was a pitcher's duel for most of the game as Louisville struggled to hit B-Rad and Miami struggled off of Louisville starter Jeff Thompson. The game was scoreless until the 6th inning when David Thompson delivered an RBI single to drive in Tyler Palmer and give Miami the 1-0 lead. Then in the bottom of the 7th, Radziewski lost his control and hit two Cardinals and walked another to go along with an infield hit and error by himself to give Louisville a 2-1 lead. Javi Salas came on in relief with the bases loaded and walked in a run and then gave up a bases clearing double to give Louisville a 6-1 lead. The Canes would rally to score three runs in the 8th as Thompson had an RBI groundout, Brad Fieger delivered a 2-RBI single to make it 6-4. Miami had 2nd and 3rd with 2 outs, but Louisville closer Nick Burdi struck out Brandon Lopez to end the threat. The Canes couldn't do anything in the 9th and fell to the Cardinals 6-4.
Miami would face Oklahoma State once again in an elimination game as the Canes lost to Louisville and Oklahoma State beat Bowling Green. Unfortunately, this time when it mattered most the Cowboys would come out on top 7-1. Andrew Suarez struggled going 6 2/3 innings while allowing five runs on six hits. Miami actually scored a run in the top of the 1st to take an early 1-0 lead, but that was the only run the Canes would score. Cowboys starter Mark Robinette went six scoreless innings and allowed just two hits. Vince Wheeland finished off Miami tossing a scoreless 7th, 8th, and 9th while also allowing just two hits. The Canes needed a good start from Suarez and they didn't get one, coupled with no offense, Miami was sent home for the offseason.